Open AccessInduction of phenotypic serum resistance of Neisseria gonorrhoeae occurs in two steps
Author(s) -
Goldner M.,
Martin P.M.V.,
Patel P.V.,
Parsons N.J.,
Smith H.
Publication year - 1984
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1984.tb00733.x
Subject(s) - neisseria gonorrhoeae , phenotype , microbiology and biotechnology , neisseriaceae , inducer , biology , complement factor b , alternative complement pathway , neisseria , guinea pig , bacteria , immunology , complement system , genetics , antibody , gene , antibiotics
The phenotypic change of susceptible Neisseria gonorrhoeae to resistance to complement mediated killing by human serum, induced by a small M r factor in guinea pig serum has been shown to be a two‐stage event. First, there appears to be adsorption of the inducing factor which per se does not confer resistance. This is then followed by a secondary, possibly metabolic, event prompted by the inducer that occurs in 3 h at 37°C.