Open AccessComparison of the antiviral action of different human interferons against DNA and RNA viruses
Author(s) -
Muñoz Alberto,
Carrasco Luis
Publication year - 1984
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1984.tb00194.x
Subject(s) - vesicular stomatitis virus , interferon , virology , biology , vesicular stomatitis indiana virus , herpes simplex virus , virus , poliovirus , rna , vesicular stomatitis , microbiology and biotechnology , hela , cell culture , gene , biochemistry , genetics
Five different interferon preparations were compared for their antiviral activity against Herpes simplex virus type 1 (HSV‐1) and several RNA viruses. The interferons used were: interferon α from human buffy coats, interferon β from human fibroblasts, interferon γ from human lymphocytes after stimulation with phytohemagglutinin (PHA), lymphoblastoid interferon from Namalva cells IFN‐α (Ly) and cloned α 2 interferon produced by Escherichia coli containing the human gene for interferon α 2 . All preparations were able to protect monolayers of HeLa cells against HSV‐1 infection when low multiplicities were used. The five IFN preparations were also tested against encephalomyocarditis (EMC) virus, poliovirus and vesicular stomatitis virus (VSV).