Open AccessInhibition of staphylococcal delta‐haemolysin by human serum lipoproteins
Author(s) -
Whitelaw D.D.,
Birkbeck T.H.
Publication year - 1978
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1978.tb01966.x
Subject(s) - hemolysin , microbiology and biotechnology , chemistry , delta , biology , biochemistry , virulence , physics , astronomy , gene
Staphylococcal 8-haemolysin, distinguished from other staphylococcal haemolysins by its low specific activity on a wide range of erythrocytes, is inhibited by normal mammalian sera [1,2] and forms a precipitin line on gel diffusion with normal sera [3,4]. In human serum a relatively constant level of inhibitor was found [5] and by immunoelectrophoresis, Kantor et al. showed that the inhibitor had the mobility of an a-globulin [4]. However the inhibitor(s) have thus far not been identified and we report here evidence that both aand/3-1ipoproteins of normal serum inhibit the action of ~-haemolysin.