Open AccessPrevalence of human herpesvirus 8 DNA in peripheral blood mononuclear cells of acute and chronic leukemia patients in Taiwan
Author(s) -
Chen ChaoHsien,
Chang ChunPin,
Wu FangYan,
Liu ChaoLi,
Peng ChingTien,
Lin ChengWen
Publication year - 2011
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2010.00768.x
Subject(s) - peripheral blood mononuclear cell , leukemia , immunology , medicine , peripheral blood , epidemiology , virology , dna , human herpesvirus , biology , virus , pathology , in vitro , genetics
Human herpesvirus 8 (HHV‐8) is associated with the development of Kaposi's sarcoma and several other human malignancies. The prevalence of HHV‐8 DNA in peripheral blood mononuclear cells (PBMCs) in Taiwanese leukemia populations has not been investigated. In this study, HHV‐8 DNA was extracted from PBMCs, and detected in 10.29% of the leukemia cases and 8.94% of the relatives' cases. In addition, the prevalence of HHV‐8 DNA in PBMCs was nonsignificantly associated with gender, age and leukemia subtypes. The study examines the prevalence of HHV‐8 DNA in PBMCs in Taiwanese leukemia and can be applied in further epidemiological studies.