Open AccessEpidemiology of invasive Streptococcus pyogenes disease in Germany during 2003–2007
Author(s) -
Imöhl Matthias,
Reinert Ralf René,
Ocklenburg Christina,
Van Der Linden Mark
Publication year - 2010
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2010.00652.x
Subject(s) - cefotaxime , streptococcus pyogenes , microbiology and biotechnology , penicillin , biology , clindamycin , levofloxacin , tetracycline , streptococcus , toxic shock syndrome , antibiotics , bacteria , staphylococcus aureus , genetics
Abstract A nationwide laboratory‐based surveillance study of invasive Streptococcus pyogenes infections was conducted in Germany. Invasive isolates ( n =586) were obtained between 2003 and 2007. Most isolates were obtained from blood (53.9%) or skin lesions (17.6%). The most common emm types were emm 1 (30.5%), emm 28 (18.3%) and emm 3 (9.6%). Overall, spe A was positive in 45.9%, spe C in 44.7% and ssa in 14.8% of isolates. Spe A was common in emm type 1 (100%) and emm type 3 (96.4%), whereas spe C was often observed in emm type 28 (93.5%). The most frequent clinical manifestations included sepsis (40.1%), necrotizing fasciitis (20.8%) and streptococcal toxic shock syndrome (16.6%). All isolates were susceptible to penicillin G, cefotaxime and levofloxacin. Tetracycline shows the highest rate of resistant or intermediate isolates with 11.6%, followed by clarithromycin (5.5%) and clindamycin (1.2%). The most prominent trend is the reduction of tetracycline‐nonsusceptible isolates from 18.6% in 2003 to 8.9% in 2007.