Open AccessIdentification of an iron‐responsive protein that is antigenic in patients with Chlamydia trachomatis genital infections
Author(s) -
Raulston Jane E.,
Miller Jeffrey D.,
Davis Caroyn H.,
Schell Maria,
Baldwin Amy,
Ferguson Kaethe,
Lane Heather
Publication year - 2007
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2007.00336.x
Subject(s) - chlamydia trachomatis , antigen , chlamydiales , biology , chlamydia , immune system , chlamydiaceae , immunology , antibody , virology , western blot , microbiology and biotechnology , gene , genetics
Chlamydia trachomatis is an important cause of immune‐mediated damage to the reproductive tract of infected patients. Certain chlamydial antigens and host genetic factors have been identified as contributing to immunopathological events, but a comprehensive understanding of specific components involved in destructive vs. protective immune responses to chlamydial infections is far from clear. In this study, it is shown that C. trachomatis ‐infected patients generate antibodies against an iron‐responsive chlamydial protein, YtgA. The identity of YtgA was confirmed by mass spectrometry following two‐dimensional polyacrylamide gel electrophoresis and Western blot analysis. This finding underscores a necessity to examine patient sera samples to identify chlamydial antigens that are likely encountered and important to the immune response during human infections.