Open AccessThe Candida albicans gene HGT12 (orf19.7094) encodes a hexose transporter
Author(s) -
Luo Lin,
Tong XingZhang,
Farley Peter C.
Publication year - 2007
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2007.00274.x
Subject(s) - phagolysosome , candida albicans , biology , hexose , microbiology and biotechnology , glucose transporter , snf3 , macrophage , mannose , corpus albicans , yeast , biochemistry , phagocytosis , phagosome , saccharomyces cerevisiae , enzyme , in vitro , insulin , endocrinology
Yeast cells of the human pathogen Candida albicans that enter the bloodstream can be engulfed by macrophage cells but survive in, and can escape from, the phagolysosome. The C . albicans gene HGT12 , which is specifically expressed during macrophage infection, encodes a protein that transports fructose, glucose and mannose. Expression of this hexose transporter along with the shift from glycolysis to gluconeogenesis that occurs in these phagocytosed cells suggests a requirement for glucose that can be supplied in part by uptake from the lumen of the phagolysosome.