Open AccessPotential role of thiol:disulfide oxidoreductases in the pathogenesis of Helicobacter pylori
Author(s) -
Kaakoush Nadeem O.,
Kovach Zsuzsanna,
Mendz George L.
Publication year - 2007
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2007.00259.x
Subject(s) - helicobacter pylori , pathogenesis , virulence , biology , microbiology and biotechnology , thiol , immunology , biochemistry , genetics , gene
Helicobacter pylori infections are responsible for a sequence of molecular events which ultimately result in the development of gastric diseases. The pathogenesis of H. pylori has been studied extensively with strong focus on the identification of virulence factors. In contrast, the involvement of thiol:disulfide oxidoreductases in bacterial pathogenesis is less well understood. This paper provides a review of the current knowledge of H. pylori putative thiol:disulfide oxidoreductases, and their potential role in promoting virulence and colonization. Several bioinformatic analyses served to complete the information on these oxidoreductases of H. pylori .