Open AccessTen years after the first Helicobacter pylori genome: comparative and functional genomics provide new insights in the variability and adaptability of a persistent pathogen
Author(s) -
De Reuse Hilde,
Bereswill Stefan
Publication year - 2007
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2007.00244.x
Subject(s) - biology , helicobacter pylori , comparative genomics , genomics , adaptation (eye) , virulence , genome , genetics , adaptability , pathogen , functional genomics , computational biology , evolutionary biology , gene , ecology , neuroscience
In this review, we summarize how genomic approaches contributed to the understanding of the biology of the recently discovered pathogen Helicobacter pylori . Comparative genomics provided new insights into H. pylori 's spectacular genetic diversity and generated exiting hypotheses on its evolutionary history. Transcriptomic studies provided original information on the mechanisms of H. pylori gastric adaptation that are central to its virulence.