Open AccessAn oral Salmonella vaccine promotes the down‐regulation of cell surface Toll‐like receptor 4 (TLR4) and TLR2 expression in mice
Author(s) -
Eguchi Masahiro,
Sekiya Yukie,
Suzuki Masato,
Yamamoto Tomoko,
Matsui Hidenori
Publication year - 2007
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2007.00240.x
Subject(s) - tlr2 , biology , microbiology and biotechnology , salmonella , listeria monocytogenes , salmonella enterica , immunization , virulence , toll like receptor , tlr4 , immune system , listeria , population , serotype , immunity , immunology , virology , innate immune system , bacteria , medicine , gene , biochemistry , genetics , environmental health
A single oral immunization with the Lon‐protease‐deficient Salmonella enterica serovar Typhimurium (strain CS2022) induced protective immunity in mice against a subcutaneous challenge with virulent Listeria monocytogenes as well as virulent Salmonella serovar Typhimurium. The populations of cell surface Toll‐like receptor 4 (TLR4) and TLR2 on peritoneal macrophages decreased at week 6 after immunization. This population decrease was not reversed after a challenge with either Salmonella or Listeria . These results suggest that oral immunization with CS2022 induced immune tolerance correlated with the down‐regulation of cell surface TLR expression. This down‐regulation may in part account for the development of cross‐protection against a Listeria challenge by immunization with CS2022.