Open AccessChanges in T‐cell subpopulations during four years of suppression of HIV‐1 replication in patients with advanced disease
Author(s) -
Lepej Snježana Židovec,
Begovac Josip,
Vince Adriana
Publication year - 2006
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2005.00034.x
Subject(s) - cd8 , cd38 , medicine , gastroenterology , cd28 , immunology , prospective cohort study , t cell , biology , immune system , stem cell , cd34 , genetics
We compared the number/percentages of naive and memory CD4 + T‐cells, CD38 + CD8 + T‐cells, and CD28 + CD4 + and CD28 + CD8 + T‐cells in patients with advanced HIV disease (baseline CD4 + count<100) with those with less advanced (baseline CD4 + cell count>100) HIV disease during 4 years of suppressive highly active antiretroviral therapy. This prospective, longitudinal study included 30 treatment‐naive patients and 32 controls. Advanced HIV‐infected patients ( n =13) gained more CD4 + T‐cells than less advanced patients ( n =11) at 1 month (median: 60 vs. 36μL −1 ), 3 months (86 vs. 14), 6 months (111 vs. 23), 12 months (174 vs. 47), 24 months (162 vs. 72) and 48 months (257 vs. 123) ( P =0.15, P <0.001, P =0.026, P =0.021, P =0.1 and P =0.06, respectively). Advanced patients gained more naive CD4 + T‐cells at 48 months compared to less advanced patients (27.3 vs. 11.4%, P =0.05). The relative gain in memory CD4 + T‐cells was greater in advanced vs. less advanced patients at 1 month (median: 6.4 vs. 1.4%), 3 months (4.3 vs. 2.0), 6 months (6.7 vs. 1.6), 12 months (6.9 vs. 2.4), 24 months (7.5 vs. 3.1) and 48 months (11.3 vs. 6.8) ( P =0.002, P =0.013, P <0.001, P =0.004, P =0.001 and P =0.015, respectively). At 48 months, CD38 + CD8 + T‐cells and naive CD4 + T‐cells reached normal values (9.2%, P =0.869 vs. controls and 47.5%, P =0.699, respectively) in less advanced patients, as did CD38 + CD8 + T‐cells in advanced patients (4.7%, P =0.309 vs. controls). The kinetics of naive and memory CD4 + T‐cell reconstitution is different in less advanced compared to advanced HIV patients.