Open AccessBrefeldin A, a cytotoxin produced by Paecilomyces sp. and Aspergillus clavatus isolated from Taxus mairei and Torreya grandis
Author(s) -
Wang Jianfeng,
Huang Yaojian,
Fang Meijuan,
Zhang Yongjie,
Zheng Zhonghui,
Zhao Yufen,
Su Wenjin
Publication year - 2002
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2002.tb00602.x
Subject(s) - paecilomyces , biology , botany , phoma , hypocreales , microbiology and biotechnology , ascomycota , biochemistry , gene
Paecilomyces sp. and Aspergillus clavatus , which were isolated from Taxus mairei and Torreya grandis from southeast China, produced toxic metabolites when grown in liquid culture. Nuclear magnetic resonance techniques, infrared spectrometry, electrospray ionization mass spectroscopy and X‐ray analysis identified brefeldin A, a bioactive metabolite produced by a number of fungal species belonging to the genera Alternaria , Ascochyta , Penicillium , Curvularia , Cercospora and Phyllosticta . This is the first report of the isolation of the cytotoxin from Paecilomyces sp. and A. clavatus . The relevance of brefeldin A to the association between these fungi and their host plants is discussed.