Open AccessThe antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats
Author(s) -
Clark Leila,
Greenbaum Carla,
Jiang Jianjie,
Lernmark Åke,
Ochs Hans
Publication year - 2002
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2002.tb00555.x
Subject(s) - biology , congenic , antibody , microbiology and biotechnology , gene , virology , immunology , genetics
Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia ( Lyp ) gene ( Lyp / Lyp ), heterozygous ( Lyp /+), or wild‐type (+/+), were immunized with the T cell‐dependent bacteriophage ΦX174 to determine effects of Lyp on primary and secondary antibody responses. The primary ΦX174 antibody response did not differ between the three different genotypes. In contrast, the secondary immune response, expressed as the peak neutralizing titer, was markedly reduced in Lyp / Lyp (9.9±3.2; mean value±S.E.M. for seven rats) compared to both Lyp /+ (51±12; n =13 ; P =0.006 ) and +/+ (100±20; n =7 ; P =0.004 ) BB rats. We suggest that the secondary antibody response to the T cell‐dependent neoantigen ΦX174 is linked in a recessive manner to genetic factor(s) in the Lyp gene region.