Open AccessFluoride modifies adhesion of Streptococcus pyogenes
Author(s) -
Cao Junkai,
Doyle R.J
Publication year - 2002
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2002.tb00550.x
Subject(s) - streptococcus pyogenes , fibronectin , microbiology and biotechnology , sodium fluoride , laminin , fluoride , streptococcus , adhesion , streptococcaceae , biology , bacteria , immunology , chemistry , extracellular matrix , biochemistry , staphylococcus aureus , antibiotics , inorganic chemistry , organic chemistry , genetics
Streptococcus pyogenes grown in the presence of subinhibitory concentrations of sodium fluoride had a diminished ability, compared to control cells, to adhere to buccal cells, collagen, fibronectin, and laminin. In addition, sodium fluoride was a competitive inhibitor of streptococcal adhesion to collagen and fibronectin, but not laminin. It is suggested that sodium fluoride may be useful in therapy or prophylaxis in infections involving group A streptococci.