Open AccessPro‐inflammatory cytokine production by synoviocytes following exposure to protein I/II, a modulin from oral streptococci
Author(s) -
Gourieux Bénédicte,
AlOkla Souad,
SchöllerGuinard Marie,
Klein JeanPaul,
Sibilia Jean,
Wachsmann Dominique
Publication year - 2001
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2001.tb01544.x
Subject(s) - cytokine , tumor necrosis factor alpha , synovial fluid , immunology , interleukin 6 , rheumatoid arthritis , synovial membrane , secretion , interleukin , microbiology and biotechnology , interleukin 8 , biology , medicine , osteoarthritis , pathology , alternative medicine
Abstract We have tested the ability of protein I/II, an adhesin from oral streptococci, to stimulate the production of pro‐inflammatory cytokines by synovial cells isolated from both rheumatoid arthritis and control patients. Protein I/II triggers synovial fluid cells to produce interleukin (IL)‐6 and IL‐8 while secretion of tumor necrosis factor‐α (TNF‐α) was less enhanced. Using fibroblast‐like synoviocytes, we found that protein I/II also exerts an immunomodulatory effect (IL‐6 and IL‐8 release) on these cells. These findings indicate that, if it gains access to the joint cavity, protein I/II could participate in the initiation and/or perpetuation of rheumatic diseases, by stimulating pro‐inflammatory cytokine release from various synovial cells.