Open AccessHIV‐1 co‐receptor CCR5 and CCR2 mutations among Greeks
Author(s) -
Papa Anna,
Papadimitriou Evagelia,
Adwan Ghaleb,
Clewley Jonathan P.,
Malissiovas Nikos,
Ntoutsos Ioannis,
Alexiou Stella,
Antoniadis Antonis
Publication year - 2000
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2000.tb01461.x
Subject(s) - biology , allele , genotype , allele frequency , virology , human immunodeficiency virus (hiv) , ccr2 , chemokine receptor ccr5 , genotype frequency , polymorphism (computer science) , genetics , receptor , gene , chemokine receptor , chemokine
The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)‐positive and HIV‐negative populations of Northern Greece was investigated. The frequency of the CCR5Δ 32 allele among the HIV‐negative subjects was 0.052, while it was approximately two‐fold lower among the seropositives, suggesting that the heterozygous genotype confers a partial resistance to the HIV infection. No significant difference in CCR2 allele frequency between the two groups was observed.