Open AccessRecombinant live Salmonella spp. for human vaccination against heterologous pathogens
Author(s) -
Bumann D.,
Hueck C.,
Aebischer T.,
Meyer T.F.
Publication year - 2000
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.2000.tb01450.x
Subject(s) - heterologous , salmonella , biology , vaccination , recombinant dna , virology , antigen , microbiology and biotechnology , attenuated vaccine , immunology , bacteria , genetics , gene , virulence
Live attenuated Salmonella spp. are promising candidates as oral vaccine delivery systems for heterologous antigens. Clinical trials have demonstrated that this approach is feasible for human vaccinations but further optimisation is necessary to obtain a better efficacy. Here, we discuss how existing clinical and pre‐clinical data can be used to guide such optimisation efforts.