Open AccessInvasive infections due to Clavispora lusitaniae
Author(s) -
Krcmery Vladimir,
Mateicka Frantisek,
Grausova Sylvia,
Kunova Alena,
Hanzen Jan
Publication year - 1999
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1999.tb01719.x
Subject(s) - amphotericin b , antifungal , microbiology and biotechnology , biology , meningitis , medicine , surgery
Three cases of Clavispora lusitaniae invasive fungal infections are reported. All three infections appeared in cancer patients presented with fungaemia, one additionally with meningitis. Two of them were breakthrough — they developed during therapy with conventional amphotericin B with a dose of 0.5 mg kg −1 day −1 . All three were cured: two with intravenous fluconazol and one with an increasing dose (1 mg kg −1 day −1 ) of amphotericin B. In one of two breakthrough cases the sensitivity of the strain to antifungals was tested against antifungal agents and showed in vitro resistance to amphotericin B (MIC 2 η ml −1 ).