Open AccessSecretory proteins of Mycobacterium habana induce a protective immune response against experimental tuberculosis
Author(s) -
Chaturvedi Vinita,
Jyoti Divya,
Srivastava Sudhir,
Gupta Hardwar P
Publication year - 1999
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1999.tb01382.x
Subject(s) - mycobacterium tuberculosis , tuberculosis , biology , microbiology and biotechnology , immune system , spleen , immunity , antigen , bacilli , immunology , secretory protein , humoral immunity , mycobacterium , bacteria , virology , secretion , medicine , pathology , biochemistry , genetics
The capacity of proteins of Mycobacterium habana TMC 5135 secreted into culture medium during the mid‐exponential growth phase (secretory proteins, SPs) to induce protective immunity against Mycobacterium tuberculosis H37Rv was studied in the mouse model. Mice immunized with SPs followed by a challenge with M. tuberculosis H37Rv showed lesser M. tuberculosis bacilli in their lung and spleen and survived longer than unimmunized controls. The findings suggest that SP antigens of M. habana are protective against tuberculosis infection.