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Aerosolised liposomal hamycin for treatment of systemic Candida infections in mice
Author(s) -
Dhuley Jayant N
Publication year - 1999
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1999.tb01347.x
Subject(s) - candida albicans , liposome , inoculation , body weight , biology , pharmacology , microbiology and biotechnology , immunology , endocrinology , biochemistry
Mice lethally infected with Candida albicans were exposed to small‐particle aerosols containing hamycin liposomes. The drug, when administered twice daily for 2 h (0.68 mg kg −1 body weight per day) on days 1, 2 and 3 post inoculation, significantly reduced the numbers of Candida organisms in the kidneys. Aerosol treatment increased the survival time of mice given two 2‐h treatments once a week for 4 weeks. A twice weekly 2‐h small particle aerosol administration of hamycin for 1, 2, or 3 weeks significantly increased both the mean time of survival and percent survival.