Open AccessSusceptibility in vitro of Helicobacter pylori to cetylpyridinium chloride
Author(s) -
Bereswill Stefan,
Vey Tanja,
Kist Manfred
Publication year - 1999
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1999.tb01281.x
Subject(s) - cetylpyridinium chloride , microbiology and biotechnology , minimum inhibitory concentration , antimicrobial , biology , antiseptic , pathogen , agar dilution , campylobacter , bacteria , agar , staphylococcus aureus , helicobacter pylori , chemistry , pulmonary surfactant , biochemistry , genetics , organic chemistry
The antimicrobial agent cetylpyridinium chloride (CPC) which is used in therapy of oro‐pharyngeal infections and for antiseptic treatment of the oral cavity is active against different bacterial species. Determination of the minimal inhibitory concentration (MIC) using the agar dilution technique revealed that the gastric pathogen Helicobacter pylori in vitro is highly susceptible to CPC as indicated by an MIC of 10 μM (3.4 μg ml −1 ) which was significantly lower than the MIC of CPC against other bacterial species, which were analyzed in comparison to H. pylori . Bacteria of the genus Campylobacter , various Streptococcus spp., Staphylococcus aureus and Escherichia coli showed higher MICs ranging from 100 μM to 2 mM. In summary, this finding renders CPC‐containing drugs candidates possibly useful for eradication or for the prevention of transmission of the gastric pathogen.