Open AccessImmune effector responses to an excretory‐secretory product of Giardia lamblia
Author(s) -
Kaur H,
Samra H,
Ghosh S,
Vinayak Virender K,
Ganguly Nirmal K
Publication year - 1999
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1999.tb01228.x
Subject(s) - biology , giardia lamblia , immune system , antibody , excretory system , giardia , immunology , antigen , immunity , microbiology and biotechnology , immunoglobulin a , effector , cellular immunity , humoral immunity , immunoglobulin g , endocrinology
The prior immunisation of mice with purified excretory‐secretory product (ESP) led to a complete failure of Giardia lamblia colonisation following challenge inoculation of these animals with trophozoites. The prior immunisation of mice with ESP resulted in a significant stimulation of local immunity as evidenced by a significant enhancement of T helper/inducer activity along with a significant increase in immunoglobulin A‐bearing cells. Further, the presence of anti‐ESP antibodies in the serum of immunised as well as immunised‐challenged animals indicated the stimulation of the systemic lymphoid system. This suggests that the ESP is highly immunogenic and it could be one of the major antigens of G. lamblia responsible for protection against the infection.