Open AccessCarbapenem‐induced endotoxin release in Gram‐negative bacterial sepsis rat models
Author(s) -
Horii Toshinobu,
Kobayashi Miya,
Nadai Masayuki,
Ichiyama Satoshi,
Ohta Michio
Publication year - 1998
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1998.tb01177.x
Subject(s) - meropenem , microbiology and biotechnology , ceftazidime , proteus mirabilis , carbapenem , serratia marcescens , klebsiella pneumoniae , pseudomonas aeruginosa , proteus vulgaris , imipenem , sepsis , biology , doripenem , escherichia coli , antibiotics , bacteria , immunology , biochemistry , antibiotic resistance , genetics , gene
The carbapenem‐induced endotoxin release was evaluated using experimental models of Gram‐negative bacterial sepsis in Wistar rats. Infections with Escherichia coli , Serratia marcescens , Klebsiella pneumoniae , Pseudomonas aeruginosa , Proteus vulgaris and Proteus mirabilis resulted in an increase of the plasma endotoxin concentration after treatment with ceftazidime and carbapenems including imipenem, panipenem, meropenem and biapenem. Except for P. aeruginosa , the plasma endotoxin concentrations after carbapenem treatment were significantly lower than those after ceftazidime treatment. It is noteworthy that treatment of P. aeruginosa sepsis with meropenem or biapenem induced significantly more endotoxin release than other carbapenems and the endotoxin concentrations induced by these carbapenems reached those of ceftazidime treatment. The plasma endotoxin concentrations appeared to correlate with the reduction of platelet counts and the elevation of both glutamic oxaloacetic transaminase and glutamic pyruvic transaminase values.