Open AccessInhibition of Helicobacter pylori sialic acid‐specific haemagglutination by human gastrointestinal mucins and milk glycoproteins
Author(s) -
Hirmo Siiri,
Kelm Sørge,
Iwersen Mathias,
Hotta Kyoko,
Goso Yukinobu,
Ishihara Kazuhiko,
Suguri Toshiaki,
Morita Minoru,
Wadström Torkel,
Schauer Roland
Publication year - 1998
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1998.tb01137.x
Subject(s) - mucin , helicobacter pylori , microbiology and biotechnology , sialic acid , biology , glycoprotein , hemagglutination , spirillaceae , gastric mucosa , chronic gastritis , gastritis , stomach , pathogen , biochemistry , immunology , antigen , genetics
Helicobacter pylori , a human gastric pathogen causing chronic gastritis and duodenal ulcer disease, has been found in large amounts in gastric mucous gel layer. Mucin preparations, separated from human gastric juices and isolated from different colon regions, were examined for their ability to inhibit haemagglutination of H. pylori with the emphasis on evaluating the role of sialic acid‐dependent haemagglutinins of the bacteria in colonisation of the stomach. The mucins showed high inhibitory activity for H. pylori , which was significantly decreased after the removal of sialic acids from the mucins. The inhibitory potencies using high molecular mass mucin‐like components from bovine milk were comparable with those obtained for gastric mucins, suggesting their possible role in the prevention of H. pylori infection.