Open AccessA study of photobactericidal activity in the phenothiazinium series
Author(s) -
Wainwright M,
Phoenix D.A.,
Marland J,
Wareing D.R.A.,
Bolton F.J.
Publication year - 1997
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1997.tb01074.x
Subject(s) - enterococcus faecalis , staphylococcus aureus , bacillus cereus , microbiology and biotechnology , escherichia coli , pseudomonas aeruginosa , biology , antibacterial activity , enterococcus , gram , bacteria , antibiotics , biochemistry , genetics , gene
The photodynamic antibacterial properties of a closely related series of commercially available phenothiazinium dyes were tested against a range of pathogenic strains of Gram‐positive ( Staphylococcus aureus , Enterococcus faecalis , Bacillus cereus ) and Gram‐negative organisms ( Escherichia coli , Pseudomonas aeruginosa ). The photosensitisers were illuminated using a non‐laser light source at a fluence of 1.75 mW cm −2 and this resulted in the enhancement of antibacterial activity in liquid culture. In several cases, illumination resulted in considerable decreases in the minimum lethal concentrations required, giving up to 100‐fold increases in bactericidal activity.