Open AccessReduced intestinal colonisation with F18‐positive enterotoxigenic Escherichia coli in weaned pigs fed chicken egg antibody against the fimbriae
Author(s) -
Zúñiga Armando,
Yokoyama Hideaki,
AlbickerRippinger Pia,
Eggenberger Ernst,
Bertschinger Hans Ulrich
Publication year - 1997
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1997.tb01041.x
Subject(s) - fimbria , biology , enterotoxigenic escherichia coli , microbiology and biotechnology , antibody , colonisation , serotype , escherichia coli , immunity , immune system , enterotoxin , immunology , colonization , biochemistry , gene
Newly weaned pigs were fed a basal diet containing either egg antibody against fimbriae F18 at a high or low level, control egg powder or no egg, and challenged with enterotoxigenic Escherichia coli with fimbriae F18. The challenge was repeated after termination of the antibody treatment. Antibody‐containing egg powder was produced by vaccination of hens with semi‐purified fimbriae of the two variants F18ab and F18ac. Pigs eating egg powder with antibody against the same fimbrial variant were fully protected, even if the vaccine for the hens was produced with a different serotype devoid of enterotoxins. The effect was dose‐dependent. The high dose of antibody against the heterologous variant of fimbriae F18 reduced colonisation at a level which was not significant. Ingestion of egg antibody partially suppressed the build‐up of anti‐colonisation immunity. Oral application of egg antibodies offers a promising approach for the prevention of infectious diseases of the digestive tract.