Open AccessProtection against generalized autoimmunity of the nervous system (GANS), a novel animal model with combined features of EAE, EAN and EAU by a recombinant HIV‐1 Tat 37–72 peptide‐based multiple T cell epitope vaccine
Author(s) -
Schluesener Hermann J
Publication year - 1997
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1997.tb01011.x
Subject(s) - immune system , immunology , experimental autoimmune encephalomyelitis , autoimmunity , biology , recombinant dna , encephalomyelitis , multiple sclerosis , autoimmune disease , central nervous system , antigen , virology , antibody , gene , endocrinology , biochemistry
A new model of multi‐compartment auto‐immune disease has been established to analyze the effects of polyvalent recombinant peptide vaccines. A synthetic gene encoding major pathogenic determinants for Lewis rats of guinea pig myelin basic protein (MBP 68–84 ), bovine interphotoreceptor retinoid binding protein (IRBP 1169–1191 ), and bovine P 2 protein (P 2,53–78 ) was used to induce Generalized Autoimmunity of the Nervous System (GANS), which is characterized by development of auto‐immune infiltration of the brain and spinal cord, the eyes, the pineal organ and the peripheral nerves. Thus, this model integrates the prominent features of three auto‐immune diseases: experimental autoimmune encephalomyelitis (EAE), neuritis (EAN) and uveitis (EAU). In this study, GANS was used to study the effect of HIV‐1 Tat 37–72 targeting peptide on vaccination by recombinant polyvalent T cell auto‐antigen vaccine. Depending on the route of administration, the recombinant vaccine effectively protects against the development of auto‐immune nervous system inflammation.