Open AccessA glucocorticoid antagonist, mifepristone affects anti‐ Candida activity of murine neutrophils in the presence of prednisolone in vitro and experimental candidiasis of prednisolone‐treated mice in vivo
Author(s) -
Abe Shigeru,
Ohnishi Megumi,
Nohmi Takao,
Katoh Masahiro,
Tansho Shigeru,
Yamaguchi Hideyo
Publication year - 1996
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1996.tb00256.x
Subject(s) - mifepristone , prednisolone , glucocorticoid , antiglucocorticoid , candida albicans , in vivo , antagonist , biology , in vitro , medicine , pharmacology , endocrinology , glucocorticoid receptor , microbiology and biotechnology , receptor , biochemistry , pregnancy , genetics
The effects of a glucocorticoid‐antagonist, mifepristone on the suppressive action of prednisolone for anti‐ Candida activity of murine neutrophils were examined. Prednisolone suppressed inhibitory activity of neutrophils to mycelial growth of Candida albicans . This suppression was cancelled in the presence of 10 −7 –10 −6 M of mifepristone in vitro. Corresponding to this in vitro action, mifepristone protected prednisolone‐treated mice from lethal C. albicans infection in vivo. These results suggest that glucocorticoid‐induced vulnerability to Candida infection may be recovered or normalized by application of mifepristone.