Open AccessLive tularemia vaccine confers protection against lethal Legionella and Listeria infections in experimental animals
Author(s) -
Belyi Yuri F.,
Tartakovskii Igor S.,
Mesheryakova Irina S.,
Petrosov Vladimir V.,
Prosorovskii Sergey V.
Publication year - 1996
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1996.tb00239.x
Subject(s) - francisella tularensis , tularemia , francisella , listeria monocytogenes , microbiology and biotechnology , legionella pneumophila , biology , legionella , listeria infection , listeria , attenuated vaccine , virology , immunity , immunology , bacteria , immune system , virulence , biochemistry , genetics , gene
The efficacy of a live Francisella tularensis vaccine strain to cause nonspecific immunity toward experimental legionellosis and listeriosis was studied. Immunisation with tularemia vaccine protected over 80% and 17% of experimental animals against subsequent lethal challenge with Legionella pneumophila and Listeria monocytogenes , respectively. The protection was maximal during the first month following immunisation and declined thereafter. In order to delineate the immunostimulatory moieties of the Francisella microbe, several cell wall proteins have been purified and characterized. However, isolated cell wall components failed to induce protection.