Open AccessImmunoglobulin G subclass antibodies to rubella virus in chronic liver disease, acute rubella and healthy controls
Author(s) -
Kalvenes May Britt,
Kalland KarlHenning,
Haukenes Gunnar
Publication year - 1996
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1996.tb00214.x
Subject(s) - rubella , subclass , rubella virus , immunology , antibody , virology , virus , biology , immunoglobulin g , liver disease , chronic liver disease , antigen , immunoglobulin m , medicine , vaccination , measles , cirrhosis , biochemistry
Ten patients with chronic liver disease, seven healthy seropositive individuals with a remote history of rubella, and three patients with acute rubella were examined for serum levels of IgG subclasses and subclass antibodies against rubella virus structural proteins. One patient with AICAH had no detectable total or rubella specific IgG3 or IgG4. The liver disease patients were hypergammaglobulinemic and had greatly raised IgG1 levels. Patients with acute rubella lacked antibodies to the rubella virus E2 protein and showed no IgG4 antibody response. The liver disease patients showed a somewhat weaker IgG4 antibody response against the core (C) protein than healthy controls. However, differences are suggested within the subclasses in antibody reactivity against the individual rubella virus antigens. It is concluded that test systems that discriminate reactivities against individual antigens have to be used for characterization of viral antibody subclass profiles.