Open AccessCD11a/CD18 and CD11b/CD18 modulation by lipoteichoic acid, N ‐acetyl‐muramyl‐α‐alanyl‐ d ‐isoglutamine, muramic acid and protein A from Staphylococcus aureus
Author(s) -
Romano Carratelli C.,
Nuzzo I.,
Bentivoglio C.,
Galdiero M.
Publication year - 1996
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1996.tb00150.x
Subject(s) - muramic acid , lipoteichoic acid , biology , cd11a , microbiology and biotechnology , cd18 , staphylococcus aureus , muramyl dipeptide , biochemistry , peptidoglycan , integrin alpha m , cell , bacteria , cell wall , in vitro , genetics
This study investigates the effect of some components of the Staphylococcus aureus cell wall [lipoteichoic acid (LTA), N ‐acetyl‐muramyl‐alanyl‐ d ‐isoglutamine (MD), muramic acid (MA) and protein A (PA)] in modulating expression of cell‐surface adhesion molecules CD11a/CD18, CD11b/CD18 on monocytes qualitatively and quantitatively. Monocytes incubated with bacterial components presented different CD11b/CD18 expressions which were dose‐dependent in contrast to controls. The results obtained demonstrated that lymphocytes incubated with bacterial components also increased the expression of CD11a/CD18. The modifications in activation of CD11a/CD18 and CD11b/CD18 expression are probably correlated with modifications of membrane fluidity measured as polarisation fluorescence (P).