Open AccessSuppression of mitogen‐induced lymphocyte proliferation by syringomycin‐E
Author(s) -
Singh Vijendra K.,
Takemoto Jon Y.
Publication year - 1996
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1996.tb00069.x
Subject(s) - pokeweed mitogen , biology , lymphocyte , mitogen activated protein kinase , cellular immunity , monoclonal antibody , in vitro , t lymphocyte , immunology , cell growth , immune system , cd3 , microbiology and biotechnology , antibody , biochemistry , concanavalin a , cd8
Syringomycin E (SR‐E) is low molecular weight bacterial lipodepsipeptide with antifungal properties. Owing to immunosuppressive activities of such compounds as cyclosporine, FK506 and rapamycin, we studied the effect of SR‐E on proliferation of human blood lymphocytes in vitro. SR‐E, by itself, had no effect but the mitogen‐induced lymphocyte proliferation was significantly suppressed. The suppressive effect was more pronounced with pokeweed mitogen (PWM) as compared to phytohemagglutinin (PHA) or monoclonal antibody to CD3 (anti‐CD3). Since these mitogens induce cellular immunity (T cell‐dependent), SR‐E may potentially be a novel immunosuppressive compound.