Open AccessSalmonella typhi does not inhibit phagosome‐lysosome fusion in human monocyte‐derived macrophages
Author(s) -
Ishibashi Yoshio,
Arai Toshihiko
Publication year - 1995
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1995.tb00175.x
Subject(s) - phagosome , monocyte , lysosome , salmonella typhi , microbiology and biotechnology , biology , macrophage , phagocytosis , salmonella , typhoid fever , in vitro , immunology , bacteria , biochemistry , enzyme , genetics , escherichia coli , gene
We examined phagosome‐lysosome fusion in Salmonella typhi ‐infected human monocyte‐derived macrophages and its relevance to the intracellular survival of this bacterium in vitro. S. typhi was found to survive and multiply in human monocyte‐derived macrophages, whereas S. typhimurium was killed easily, indicating that the survival of Salmonella serovars is host‐specific. Neither S. typhi nor S. typhimurium inhibited phagosome‐lysosome fusion in human monocyte‐derived macrophages. No difference between the phagosome‐lysosome fusibilities of freshly prepared human monocytes and monocyte‐derived macrophages was observed. These results suggest that S. typhi may survive by adapting to the conditions within fused phagolysosomes of human monocyte‐derived macrophages.