Open AccessA monoclonal antibody against T‐cell receptor αβ induces endogenous cytokines and prevents mice from a lethal infection with Listeria monocytogenes
Author(s) -
Nakane Akio,
Nishikawa Shinsuke,
Sasaki Sanae,
Miura Tomisato,
Asano Misako,
Kohanawa Masashi,
Minagawa Tomonori
Publication year - 1995
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1995.tb00162.x
Subject(s) - biology , monoclonal antibody , cd8 , t cell receptor , cytokine , t cell , tumor necrosis factor alpha , immunology , antibody , microbiology and biotechnology , antigen , immune system
In vivo induction of cytokines by a monoclonal antibody (mAb) against T‐cell receptor (TCR) αβ and the protective effect induced by the mAb on a lethal infection with Listeria monocytogenes were studied. Injection of anti‐TCR αβ mAb induced rapid production of endogenous tumour necrosis factor in the spleens, and gamma interferon and interleukin‐6 in the bloodstreams and spleens of mice. Administration of anti‐CD4 mAb, anti‐CD8 mAb, or anti‐Thy1.2 mAb resulted in suppression of anti‐TCR αβ mAb‐induced endogenous cytokine production. Mice were protected against lethal L. monocytogenes infection when treated with anti‐TCR αβ mAb. The protective effect was not demonstrated in CD4 + cell‐ or CD8 + cell‐depleted mice. These results suggest that anti‐TCR αβ mAb shows a protective effect on a lethal infection with L. monocytogenes in mice and that the mAb‐induced endogenous cytokines might be involved in the effect of anti‐TCR αβ mAb.