Open AccessEmergence of tetracycline resistance due to a multiple drug resistance plasmid in Vibrio cholerae O139
Author(s) -
Yamamoto Tatsuo,
Nair G.Balakrish,
Takeda Yoshifumi
Publication year - 1995
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1995.tb00099.x
Subject(s) - tetracycline , kanamycin , microbiology and biotechnology , vibrio cholerae , ampicillin , biology , gentamicin , streptomycin , chloramphenicol , plasmid , cholera , trimethoprim , virology , sulfamethoxazole , antibiotic resistance , drug resistance , el tor , multiple drug resistance , antibiotics , bacteria , genetics , gene
Of the 173 clinical strains of Vibrio cholerae O139 isolated from India, Bangladesh, and Thailand tested, six strains from India were resistant to tetracycline, ampicillin, chloramphenicol, kanamycin, and gentamicin. These six strains harbored a self‐transmissible plasmid that mediated resistance to tetracycline, ampicillin, chloramphenicol, kanamycin, gentamicin, sulfamethoxazole, trimethoprim, and O/129. The multiple drug resistance plasmids were 200 kb in size and belonged to the incompatibility group C. Although a majority of the O139 strains (94.8%) were highly resistant to streptomycin, sulfamethoxazole, trimethoprim, and O/129, the tetracycline‐susceptible strains so far tested were plasmid‐negative. The data suggest the existence of two distinct multiple antimicrobial agent resistance (MAR) patterns in V. cholerae O139.