Open AccessAssociation of Helicobacter pylori and gastric autoimmunity: A population‐based study
Author(s) -
Uibo Raivo,
Vorobjova Tamara,
Metsküla Kaja,
Kisand Kalle,
Wadström Torkel,
Kivik Tiiu
Publication year - 1995
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1995.tb00079.x
Subject(s) - helicobacter pylori , autoimmune gastritis , autoimmunity , molecular mimicry , biology , gastritis , autoantibody , parietal cell , caga , immunology , spirillaceae , population , gastric mucosa , stomach , gastroenterology , antigen , genetics , antibody , medicine , gene , environmental health , virulence , biochemistry
Based on clinical studies, a negative association between Helicobacter pylori and autoimmune corpus gastritis is described. In the present investigation of an unselected population of 1461 adults we can state, however, that there exists a relationship between H. pylori infection and the development of gastric corpus autoimmunity. As confirmation for the gastric autoantibody development through molecular mimicry, a high homology (72% in 25 amino acid overlap) between the beta subunit of H. pylori urease and that of H + K + ATPase, the gastric parietal cell autoantigen, was revealed.