Open AccessPotential animal models of Helicobacter pylori infection in immunological and vaccine research
Author(s) -
Engstrand L.
Publication year - 1995
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1995.tb00042.x
Subject(s) - helicobacter pylori , immune system , gastritis , immunology , chronic gastritis , biology , vaccination , disease , animal model , in vivo , gastric mucosa , medicine , stomach , pathology , biochemistry , genetics , microbiology and biotechnology , endocrinology
Presence of Helicobacter pylori in the human gastric mucosa is associated with chronic gastritis and promotes the formation of peptic ulceration. Furthermore, long‐term gastritis caused by the bacteria represents an increased risk of developing gastric cancer. Much controversy remains about the pathogenic mechanisms by which H. pylori can induce disease because of the limitations of animal models and the relevance of in vitro observations to the in vivo disease process. Studies of putative pathogenic factors such as induction of inflammatory mediators and immune evasion are required to understand how to design a vaccine against the infection. Vaccine adjuvants, delivery systems and therapeutic vaccination are likely to be the areas of major progress in the future. Data related to immunological aspects and vaccine development in potential animal models are reviewed.