Open AccessImpairment of the human phagocyte oxidative responses caused by Leishmania lipophosphoglycan (LPG): In vitro studies
Author(s) -
Brandonisio O.,
Panaro M.A.,
Marzio R.,
Marangi A.,
Faliero S.M.,
Jirillo E.
Publication year - 1994
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1994.tb00425.x
Subject(s) - lipophosphoglycan , phagocyte , biology , in vitro , oxidative phosphorylation , leishmania , immunology , chronic granulomatous disease , microbiology and biotechnology , leishmania donovani , leishmaniasis , phagocytosis , biochemistry , parasite hosting , visceral leishmaniasis , world wide web , computer science
Lipophosphoglycan (LPG), a surface glycoconjugate of Leishmania promastigotes, has been reported as playing an active role in protecting the parasite within phagolysosomes, by an impairment of monocyte oxidative responses. In this study the effect of LPG on the oxidative burst of human peripheral monocytes, eosinophils and neutrophils was evaluated. Our results demonstrated that either superoxide anion (O 2 − ) or hydrogen peroxide (H 2 O 2 ) release by LPG‐pretreated cells was diminished, emphasizing the ability of this glycoconjugate to impair the oxidative activity of all phagocytes.