Open AccessStreptokinase alleles and disease association in group A streptocci
Author(s) -
Haase Antje,
Melder Angela,
Kemp David,
Mathews John
Publication year - 1994
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1994.tb00013.x
Subject(s) - allele , biology , streptokinase , glomerulonephritis , locus (genetics) , typing , microbiology and biotechnology , genotype , group a , streptococcus , genetics , immunology , virology , gene , medicine , bacteria , kidney , myocardial infarction
Allele‐specific oligonucleotides were used for PCR‐based typing of the streptokinase locus of group A streptococcal strains, including well characterized type strains, isolates from patients with acute poststreptococcal glomerulonephritis and strains from Aboriginal communities in the Northern Territory of Australia. The streptokinase SKN allele, previously thought to be associated with glomerulonephritis, was no more frequent in nephritogenic than in non‐nephritogenic streptococcal strains in this collection.