Open AccessAnalysis of intestinal flora of a patient with congenital absence of the portal vein
Author(s) -
Kamiya S.,
Taniguchi Izumi,
Yamamoto Takako,
Sawamura S.,
Kai M.,
Ohnishi N.,
Tsuda M.,
Yamamura M.,
Nakasaki H.,
Yokoyama S.,
Mitomi T.,
Ozawa A.
Publication year - 1993
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1993.tb00384.x
Subject(s) - bifidobacterium bifidum , microbiology and biotechnology , lactobacillus casei , biology , bacteroides , bifidobacterium , eubacterium , bacteroides thetaiotaomicron , bifidobacterium breve , peptostreptococcus , bifidobacterium longum , lactobacillus , bacteria , genetics
A 14‐year‐old female patient, admitted for a closer examination of liver tumour (hepatocellular adenoma), was diagnosed as having a congenital absence of the portal vein. The blood ammonia level (approximately 120 μg dl −1 ) in the superior mesenteric vein was markedly low compared to the normal value of 300–350 μg dl −1 in the portal vein. The decreased ammonia concentration and urease activity of the patient's faeces were demonstrated. The dominant intestinal flora in the faeces of the patient, before operation, was Bifidobacterium sp., Bifidobacterium breve, Bifidobacterium lonqum, Lactobacillus plantarum , and after the operation Bacteroides vulgatus, Veillonella parvula, Peptococcus magnus Bifidobacterium longum . In contrast, Bifidobacterium bifidum, Bacteroides ureolyticus, Bacteroides ovatus and Bacteroides distasonis, B. ovatus, Bifidobacterium adolescentis were dominant flora in the faeces of two healthy volunteers, respectively. Among microorganisms isolated from the patient, Morganella morganii, Candida sp., Eubacterium aerofacience and Eubacterium rectale were strongly positive in urease activity in vitro; Streptococcus mitior, Staphylococcus intermedius, Micrococcus kristinae, Selenomonas ruminantum, Bacteroides ureolyticus and Lactobacillus casei ss. pseudoplantarum from the healthy volunteers. These results imply the homeostatic regulation system of faecal ammonia concentration by urease‐producing microorganisms in the patient.