Open AccessMetabolic engineering, synthetic biology and systems biology
Author(s) -
Nielsen Jens,
Pronk Jack T.
Publication year - 2012
Publication title -
fems yeast research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 92
eISSN - 1567-1364
pISSN - 1567-1356
DOI - 10.1111/j.1567-1364.2011.00783.x
Subject(s) - biology , milestone , saccharomyces cerevisiae , whole genome sequencing , sequence (biology) , yeast , computational biology , synthetic biology , genome , genetics , metabolic engineering , evolutionary biology , gene , history , archaeology
The completion, in 1996, of the genome sequence of the Saccharomyces cerevisiae laboratory strain S288C represents a watershed in yeast research. In their historic Science publication marking this milestone, Goffeau and colleagues commented that ‘new graduate students are already wondering how we all managed in the “dark ages” before the sequence was completed’.The words ‘the sequence’ in the above-mentioned quote illustrate how fast yeast research continues to develop today. Costs of whole-genome sequencing have decreased so spectacularly that it is now an integral part of the yeast research toolkit, and annotated …