Open AccessHypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeast
Author(s) -
Biliński Tomasz,
ZadrągTęcza Renata,
Bartosz Grzegorz
Publication year - 2012
Publication title -
fems yeast research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 92
eISSN - 1567-1364
pISSN - 1567-1356
DOI - 10.1111/j.1567-1364.2011.00759.x
Subject(s) - biology , yeast , cellular aging , phenomenon , evolutionary biology , genetics , telomere , dna , epistemology , philosophy
This paper summarizes numerous arguments demonstrating that the hypothesis of accumulation of the senescence factor, which was the basis for introducing yeast to the group of model organisms of gerontology, finds no experimental support. Among several candidates for the role of the causative agents of replicative aging, only one – hypertrophy – always accompanies symptoms of aging, not only in Saccharomyces cerevisiae , but also in Schizosaccharomyces pombe .