Open AccessFunctional characterization of the regulators of calcineurin in C andida glabrata
Author(s) -
Miyazaki Taiga,
Izumikawa Koichi,
Nagayoshi Yohsuke,
Saijo Tomomi,
Yamauchi Shunsuke,
Morinaga Yoshitomo,
Seki Masafumi,
Kakeya Hiroshi,
Yamamoto Yoshihiro,
Yanagihara Katsunori,
Miyazaki Yoshitsugu,
Kohno Shigeru
Publication year - 2011
Publication title -
fems yeast research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 92
eISSN - 1567-1364
pISSN - 1567-1356
DOI - 10.1111/j.1567-1364.2011.00751.x
Subject(s) - calcineurin , biology , candida glabrata , serine , microbiology and biotechnology , inhibitory postsynaptic potential , phosphatase , mediator , biochemistry , antifungal , enzyme , transplantation , medicine , surgery , neuroscience
The serine‐threonine‐specific protein phosphatase calcineurin is a key mediator of various stress responses in fungi. Herein, we characterized functions of the endogenous regulators of calcineurin ( RCN s), Rcn1 and Rcn2, in the pathogenic fungus C andida glabrata . Rcn1 exerted both inhibitory and stimulatory effects on calcineurin signaling, but Rcn2 displayed only inhibitory activity. Phenotypic analyses of C . glabrata strains lacking either RCN s, calcineurin, or both revealed that calcineurin requires Rcn1, but not Rcn2, for antifungal tolerance in C . glabrata .