Open AccessADH1 expression inversely correlates with CDR1 and CDR2 in Candida albicans from chronic oral candidosis in APECED (APS‐I) patients
Author(s) -
Siikala Emilia,
Bowyer Paul,
Richardson Malcolm,
Saxen Harri,
Sanglard Dominique,
Rautemaa Riina
Publication year - 2011
Publication title -
fems yeast research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 92
eISSN - 1567-1364
pISSN - 1567-1356
DOI - 10.1111/j.1567-1364.2011.00739.x
Subject(s) - biology , candida albicans , azole , alcohol dehydrogenase , gene , microbiology and biotechnology , gene expression , cancer research , immunology , genetics , ethanol , antifungal , biochemistry
Expression of the alcohol dehydrogenase gene ADH1 , which converts ethanol into carcinogenic acetaldehyde, significantly inversely correlated with the expression of CDR1 and CDR2 , genes linked to azole resistance in Candida albicans isolated from chronic oral candidosis in autoimmune polyendocrinopathy–candidosis–ectodermal dystrophy (APECED, APS‐I) patients. This is a novel link between candidal two‐carbon metabolism genes and azole resistance.