Open AccessIncreased potency of a novel d ‐β‐naphthylalanine‐substituted antimicrobial peptide against fluconazole‐resistant fungal pathogens
Author(s) -
Wang ChihWei,
Yip BakSau,
Cheng HisTsung,
Wang AnHuei,
Chen HengLi,
Cheng JyaWei,
Lo HsiuJung
Publication year - 2009
Publication title -
fems yeast research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 92
eISSN - 1567-1364
pISSN - 1567-1356
DOI - 10.1111/j.1567-1364.2009.00531.x
Subject(s) - antimicrobial , fluconazole , peptide , biology , antifungal , broth microdilution , microbiology and biotechnology , potency , antimicrobial peptides , yeast , minimum inhibitory concentration , in vitro , biochemistry
The antifungal activities of the known antimicrobial peptide, P‐113, as well as a new type of Trp‐rich peptide, Ac‐KWRRWVRWI‐NH 2 , Pac‐525, and its modified peptide, d ‐Nal‐Pac‐525, were determined using the broth microdilution method in three different media. All peptides had similar activities against yeast pathogens in low‐salt LYM media. However, only d ‐Nal‐Pac‐525 retained its antifungal activity in the media containing high concentrations of salt. Hence, d ‐Nal‐Pac‐525 has the potential of becoming a promising antifungal agent, especially for fungal pathogens with intrinsic resistance to fluconazole.