Open AccessSaccharomyces kluyveri as a model organism to study pyrimidine degradation
Author(s) -
Beck Halfdan,
Dobritzsch Doreen,
Piškur Jure
Publication year - 2008
Publication title -
fems yeast research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 92
eISSN - 1567-1364
pISSN - 1567-1356
DOI - 10.1111/j.1567-1364.2008.00442.x
Subject(s) - organism , yeast , saccharomyces cerevisiae , model organism , biology , nucleic acid , pyrimidine , saccharomyces , degradation (telecommunications) , biochemistry , computational biology , genetics , gene , computer science , telecommunications
The yeast Saccharomyces kluyveri ( Lachancea kluyveri ), a far relative of Saccharomyces cerevisiae , is not a widely studied organism in the laboratory. However, significant contributions to the understanding of nucleic acid precursors degradation in eukaryotes have been made using this model organism. Here we review eukaryotic pyrimidine degradation with emphasis on the contributions made with S. kluyveri and how this increases our understanding of human disease. Additionally, we discuss the possibilities and limitations of this nonconventional yeast as a laboratory organism.