Open AccessNeurosteroids on the Epilepsy Chessboard—Keeping Seizures in Check
Author(s) -
Rogawski Michael A.
Publication year - 2010
Publication title -
epilepsy currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 22
eISSN - 1535-7511
pISSN - 1535-7597
DOI - 10.1111/j.1535-7511.2010.01388.x
Subject(s) - neuroactive steroid , epilepsy , inhibitory postsynaptic potential , medicine , anticonvulsant , neuroscience , receptor , pharmacology , steroid , endogeny , hormone , gabaa receptor , endocrinology , psychiatry , biology
Endogenous Neurosteroid Synthesis Modulates Seizure Frequency . Lawrence C, Martin BS, Sun C, Williamson J, Kapur J. Ann Neurol 2010;67(5):689–693. Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by γ‐aminobutyric acid receptors and have anticonvulsant action.