Open AccessApoE, MemorE, and EpilepsE
Author(s) -
Hirsch Lawrence J.
Publication year - 2007
Publication title -
epilepsy currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 22
eISSN - 1535-7511
pISSN - 1535-7597
DOI - 10.1111/j.1535-7511.2007.00208.x
Subject(s) - temporal lobe , epilepsy , apolipoprotein e , medicine , nonverbal communication , audiology , verbal memory , memory impairment , neurology , psychology , neuroscience , psychiatry , developmental psychology , disease , cognition
Busch RM, Lineweaver TT, Naugle RI, Kim KH, Gong Y, Tilelli CQ, Prayson RA, Bingaman W, Najm IM, Diaz‐Arrastia R. Neurology 2007;68(6):409–414. OBJECTIVE: To investigate the relationship between the apolipoprotein (ApoE) 4 allele and memory performance (verbal and nonverbal) in patients with medically intractable temporal lobe epilepsy (TLE) who underwent temporal lobectomy. METHODS: Presurgical and postsurgical memory performance was examined in 87 adult patients with TLE (4 = 22; non‐4 = 65) to determine whether the expression of ApoE‐4 may be associated with memory performance in this population and to examine how this relationship may be affected by duration of epilepsy. RESULTS: There was a significant interaction between ApoE‐4 status and duration of epilepsy such that 4 carriers with a long duration of epilepsy demonstrated the poorest memory performance on both verbal and nonverbal measures. This relationship was observed both before and after temporal lobectomy, with little change in test performance over time. CONCLUSIONS: The ApoE‐4 allele interacts with longstanding seizures to affect memory performance, both verbal and nonverbal, in patients with medically intractable temporal lobe epilepsy.