Open AccessThe Status of Intravenous Valproate for Status
Author(s) -
Hirsch Lawrence J.
Publication year - 2007
Publication title -
epilepsy currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 22
eISSN - 1535-7511
pISSN - 1535-7597
DOI - 10.1111/j.1535-7511.2007.00185.x
Subject(s) - status epilepticus , medicine , phenytoin , anticonvulsant , refractory (planetary science) , valproic acid , epilepsy , anesthesia , neurology , pediatrics , pharmacology , psychiatry , physics , astrobiology
Misra UK, Kalita J, Patel R. Neurology 2006;67(2):340–342. Sixty‐eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in the VPA group and 42% in the PHT group. As a second choice in refractory patients, VPA was effective in 79% and PHT was effective in 25%. The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.