Open AccessNeurovascular Coupling and Epilepsy: Hemodynamic Markers for Localizing and Predicting Seizure Onset
Author(s) -
Schwartz Theodore H.
Publication year - 2007
Publication title -
epilepsy currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 22
eISSN - 1535-7511
pISSN - 1535-7597
DOI - 10.1111/j.1535-7511.2007.00183.x
Subject(s) - ictal , epilepsy , medicine , cerebral blood flow , neurovascular bundle , electroencephalography , hemodynamics , epileptic seizure , cardiology , neuroscience , anesthesia , pathology , psychology , psychiatry
Hemodynamic surrogates of epileptic activity are being used to map epileptic foci with PET, SPECT, and fMRI. However, there are few studies of neurovascular coupling in epilepsy. Recent data indicate that cerebral blood flow, although focally increased at the onset of a seizure, may be temporarily inadequate to meet the metabolic demands of both interictal and ictal epileptic events. Transient focal tissue hypoxia and hyperperfusion may be excellent markers for the epileptic focus and may even precede the onset of the ictal event.